Download PDF by Chester S. Ho (Eds.): Animal Cell Bioreactors

By Chester S. Ho (Eds.)

ISBN-10: 0409901237

ISBN-13: 9780409901238

Animal mobile tradition is chargeable for a number of medically vital items, comparable to vaccines, antibodies, hormones, cytokines, progress components and enzymes. As those items are advancing towards commercialization, the biotechnology has swiftly elevated the capability requirement for large-scale ''in vitro'' creation of animal cells and their items. This ebook makes a speciality of the underlying ideas and methods at the back of ''in vitro'' telephone cultures

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T h e m e m b r a n e viscosity ( a n d also o t h e r m e chanicochemical properties) can increase several t i m e s as a result of a p propriate cross—linking of surface p r o t e i n s e m b e d d e d in the p l a s m a m e m b r a n e (Chasis et al. 1985). T h e s e chemical stimuli are typically present in m e d i a a n d t h u s m o d u l a t e the cell stiffness. 2) (Elson 1988). T h e wide range of cytosolic viscosities only reflects t h e n o n n e w t o n i a n n a t u r e of cytoplasm: As t h e shear rate goes d o w n , t h e m e a s u r e d viscosity goes u p (Valberg a n d Albertini 1985).

It can yield m o d u l i of cellular viscosity a n d elasticity (Elson 1988). Simply put, viscoelastic properties can be u n d e r s t o o d as a c o m b i n a t i o n (in series a n d in parallel) of springs a n d a d a s h p o t (Figure 2 - 1 2 ) . T h e spring represents the elastic force ( H o o k e ' s law) a n d t h e d a s h p o t is the viscosity ( N e w t o n i a n viscosity). T h e series spring k 2 allows a n i m m e d i a t e elastic response, the parallel k{ p e r m i t s eventual recovery.

Similarly, a n c h o r a g e - d e p e n d e n t cells m a y grow vigorously before reaching a confluency o n a s u p p o r t (be it m i crocarrier or highly m a c r o p o r o u s matrix). At this point, proliferation is considerably reduced a n d a culture will reach a m a i n t e n a n c e status, p r o vided a c o n v e n i e n t m e d i a switch is p r o v i d e d (from s e r u m to serum-free media). T h e nutrient u p t a k e is usually reduced to a m i n i m u m (as e v i d e n c e d by radiolabeled a m i n o acid or nucleotide(s) uptake, oxygen, a n d glucose uptake).

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Animal Cell Bioreactors by Chester S. Ho (Eds.)


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