By Eliana Scemes, David C. Spray
Astrocytes play different roles in crucial anxious method (CNS) functionality and disorder, and the connections that the astrocyte makes with different cells of the mind are crucial for numerous vital neural projects. Bringing jointly contributions from overseas specialists on the best in their box, Astrocytes: Wiring the mind emphasizes mobile connections and surveys the most up-tp-date findings on astrocyte task. the 1st component of the booklet identifies significant astrocyte biomarkers and describes how they outline the several connectivity domain names. subsequent, the e-book examines the function of thes. Read more...
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Additional resources for Astrocytes : Wiring the Brain
14 Harold K. Kimelberg What substances normally travel through the gap junctions, and does this affect the domain concept of astrocytes and functional implications that might flow therefrom? The syncytium has been and is still viewed as something that links individual astrocytes to achieve complex functions. , 2009). After 50 years the first has not been resolved and the latter is a much more recent proposal that is still in its very early stages of formulation and experimentation. I now discuss both of these topics, as well as the issue of what signals (Ca2+) or energy substrates and metabolites (as in the astrocyte-neuron lactate-shuttle hypothesis [ANLSH]) to pass through the syncytium.
1); for instance, the perisynaptic processes are extensively labeled with transmitter-related molecules such as glutamate and Gamma aminobutyric acid (GABA) transporters and glutamatergic, purinergic, and adrenergic receptors (Wolff and Chao 2004), while at the interglial and perivascular processes, gap junctions and aquaporins are the main biomarkers, respectively (Dermietzel 1974, Nielsen et al. 1997, Nagelhus et al. 1998, Rash and Yasumura 1999). In this chapter we will focus on three groups of proteins that are abundantly expressed in astrocytes: the gap junctions, the purinergic P2 receptors, and the aquaporins.
2005). Astrocytes, from brain glue to communication elements: the revolution continues. Nat Rev Neurosci 6: 626–640. Wikipedia. (2010). Rudolf Virchow. org/wiki/Wikipedia. Winder DG, Ritch PS, Gereau RW, Conn PJ. (1996). Novel glial-neuronal signalling by coactivation of metabotropic glutamate and b-adrenergic receptors in rat hippocampus. J Physiol (Lond) 494: 743–755. Xu G, Wang W, Kimelberg HK, Zhou M. (2009). Electrical coupling of astrocytes in rat hippocampal slices under physiological and simulated ischemic conditions.
Astrocytes : Wiring the Brain by Eliana Scemes, David C. Spray