Basic & Clinical Pharmacology (LANGE Basic Science) 10th - download pdf or read online

By Bertram Katzung

ISBN-10: 0071451536

ISBN-13: 9780071451536

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Extra info for Basic & Clinical Pharmacology (LANGE Basic Science) 10th edition

Example text

If the -adrenoceptor blockade cannot be overcome, excess effects of the drug must be antagonized "physiologically," ie, by using a pressor agent that does not act via receptors. Antagonists can function noncompetitively in a different way; that is, by binding to a site on the receptor protein separate from the agonist binding site and thereby preventing receptor activation without blocking agonist binding. Although these drugs act noncompetitively, their actions are reversible if they do not bind covalently.

Maximal Efficacy This parameter reflects the limit of the dose-response relation on the response axis. Drugs A, C, and D in Figure 2–15 have equal maximal efficacy, while all have greater maximal efficacy than drug B. The maximal efficacy (sometimes referred to simply as efficacy) of a drug is obviously crucial for making clinical decisions when a large response is needed. It may be determined by the drug's mode of interactions with receptors (as with partial agonists, described above)* or by characteristics of the receptor-effector system involved.

Pharmacologic potency can largely determine the administered dose of the chosen drug. For therapeutic purposes, the potency of a drug should be stated in dosage units, usually in terms of a particular therapeutic end point (eg, 50 mg for mild sedation, 1 mcg/kg/min for an increase in heart rate of 25 beats/min). 2, 10, etc), may be used in comparing one drug with another. Maximal Efficacy This parameter reflects the limit of the dose-response relation on the response axis. Drugs A, C, and D in Figure 2–15 have equal maximal efficacy, while all have greater maximal efficacy than drug B.

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Basic & Clinical Pharmacology (LANGE Basic Science) 10th edition by Bertram Katzung


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